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Diabetic and Insulin-Resistant Patients Diabetes and insulin resistance impair growth hormone dynamics and Sermorelin response

Orthop J Sports Med

Besides lysosomal cholesterol accumulation, mitochondrial cholesterol loading has been shown to sensitize to TNF/Fas-induced steatohepatitis due to mGSH depletion (Mari et al., 2006), and hence it is conceivable that the intracellular cholesterol trafficking to different compartments (i.e., lysosomes and mitochondria) determines APAP hepatotoxicity by different mechanisms including oxidative stress/mitochondrial dysfunction and impaired mitophagy

doi: 10.1038/nature03587

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